Artecoll utilizes the body's natural ability to encapsulate foreign bodies by the formation of connective tissue surrounding the PMMA microspheres. The process of encapsulation of the microspheres by the body's own connective tissue (collagen) is complete in about 3 months. Absorption (phagocytosis) and/or dislocation of the microspheres is prevented by the encapsulation of each individual microsphere with connective tissue.

Depending on the patient and the correction to be made, a second or third injection may be needed if the degree of correction from the first injection is not optimal. Artecoll is a long-lasting implant. Unlike collagen which lasts 3-6 months, Artecoll's effect lasts for at least 5 years or more, depending on the patient. The implant remains for the life of the patient. An over correction is not recommended with Artecoll.

Artecoll is extremely safe. There have been no reports of rejection of the PMMA microspheres. PMMA has been used since the early 1930's in dental prostheses, and since 1947, when the first hip prosthesis was introduced. Many scientific articles on bone repair have mentioned the chemical inertness and biocompatibility of PMMA.

The improved results should be visible at least five years or longer depending on the patient. The implant will remain for the rest of the patient's life. The cosmetic effect of the implant will diminish over time as new wrinkles are formed.